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New Insights of HLA Class I Association to Behcet Disease in Portuguese Patients

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New Insights of HLA Class I Association to Behcet Disease in Portuguese Patients

Andreia Bettencourt, Clara Pereira, Luísa Carvalho, Cláudia Carvalho, José Vaz Patto, Marina Bastos, Ana Martins Silva, Rui Barros, Carlos Vasconcelos, Paulo Paiva, Luciana Costa, Paulo P Costa, Denisa Mendonça, João Correia, Berta Martins Silva

Abstract

Background: Behçet’s disease (BD) is a systemic vasculitis of unknown aetiology. Genetic factors and infectious agents seem to be implicated in the aetiology and pathogenesis of the disease. Class I human leukocyte antigen (HLA)-B51 is a well known genetic factor associated with BD in many ethnic groups. Objectives: To analyse the influence of HLA-B*51 and other HLA class I alleles in BD susceptibility in a Portuguese population and its association with disease severity. Methods: The study groups consisted of 78 BD patients and 208 healthy controls. The patients were classified into two severity groups (mild [n=31], severe [n=47]) as described by Gul et al (Rheumatology, 2001). Results: As expected, a higher frequency of HLA-B*51 was found in BD patients when compared to controls (41.0% vs. 22.6%, OR=2.38, 95%CI=1.37-4.16). The frequencies of HLA-Cw*02, HLA-Cw*15 and HLA-Cw*16 alleles were significantly higher in patients than in controls (26.9% vs 13.5%, OR=2.37, 95%CI=1.25-4.49; 23.1% vs 10.6%, OR=2.54, 95%CI=1.28-5.04 and 17.9% vs 7.2%, OR=2.81, 95%CI=1.29-6.15, respectively). The HLA-B*07 and the HLA-Cw*07 alleles were underrepresented in the patients group (5.1% vs 17.3%, OR=0.258, p=0.014 and 21.8% vs 43.3%, OR=0.365, p=0.001 respectively). Regarding severity, HLA-B*27 frequency was higher in the severe group (17.0%) compared to controls (8.7%) and to the mild group (p=0.019). Conclusions: In this population of Portuguese BD patients, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD. The association of HLA-B*27 with disease severity suggests that this allele is important as a prognostic factor.

Key words: Behçet’s disease; HLA class I; Portugal; disease severity.

UMIB-ICBAS/University of Porto, Portugal – Phone: +351 22 2062255, Fax: +351 222062232
Department of Internal Medicine, Hospital Geral de Santo António, Porto, Portugal
Immunogenetics Laboratory- INSA- Dr. Ricardo Jorge, Porto, Portugal
Portuguese Institute of Rheumatology – Lisboa, Portugal
São Teotónio Hospital – Viseu, Portugal
Department of Neurology, Hospital Geral de Santo António, Porto, Portugal
Unidade de ID Immunology-INSA-Dr. Ricardo Jorge, Lisboa, Portugal
Department of Population Studies, Biometry Laboratory, ICBAS/IBMC Porto,
Portugal

Corresponding author:
Andreia Bettencourt
UMIB – Instituto de Ciências Biomédicas Abel Salazar
Largo Prof. Abel Salazar, 2
4099-003 Porto, Portugal
Phone: +351222062255
Fax: +351222062232
ambettencourt@icbas.up.pt

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2016-07-13T09:21:08+00:00 2008-1-17|Categories: Doença de Behçet|Tags: , , , |